Hot Melt Extruder

Product Information

Purpose

Our recently developed One-Step Solid Dispersion Granulators is a cutting-edge solution that was developed specially for the pharmaceuticals industry. It streamlines the granulation process and is widely used for a whole host of solid dispersion applications such as masking tastes, improving solubility, providing targeted multifunctional drug release, and even directly preparing sustained-release granules. The design and construction are proficiently poised to avail the evolving demands of pharmaceutical formulation, in precision, efficiency and consistency.

Working Principle

In this procedure, the raw materials are fed into the main hopper with the aid of a quantitative feeder, followed by a twin screw mechanism that ensures even conveying combined with segmented heating progressively rising in temperature until they get fused on-going through the system. After that, they pass through a programmable orifice plate all along their course as warmth decreases gradually.

The outcome

A firm, dense strip, which is then cut and sheared by a downstream system into uniform sizes granules. Hence, time is saved, steps are cut down, and reproducibility is improved through this complete one-step transformation from raw material to finished granules.

Key Features

Our recently developed One-Step Solid Dispersion

  • Versatile Feeding System
    Supports a variety of materials via vibrating feeders and twin-screw feeders, ensuring flexible and precise dosing.

  • Efficient Heating
    Dual-zone segmented electric heating for upper and lower barrels ensures even and consistent thermal distribution.

  • Accurate Temperature Control
    Multi-stage feedback system maintains stable heating within ±0.5°C, ensuring process reliability and repeatability.

  • Live Extrusion Monitoring
    Real-time current monitoring and torque feedback protect the twin-screw, enhancing its lifespan and optimizing process safety.

  • Dual Cooling Mechanism
    Integrated water and air cooling helps maintain consistent temperatures and stabilizes output quality.

  • Modular Twin-Screw Design
    Combines multiple functions—mixing, pressurizing, melting, extruding, and cooling—to ensure full fusion of actives and excipients.

  • Custom Orifice Plates
    Offers flexibility with interchangeable extrusion dies for different material properties and desired output shapes.

  • Multi-Stage Venting
    Strategically placed vents release air and moisture during melting, reducing extrusion pressure and enhancing final product quality.

  • Customizable Shearing Device
    Adjustable shearing heads allow for the production of uniform granules, tailored to different formulation needs.

  • GMP Compliant & User-Friendly
    Easy to disassemble and clean, meets GMP standards, offers three-level password access, and features PLC automation with data logging and USB export.

  • Expandability
    Supports continuous wet granulation for additional flexibility in processing techniques.

 Specifications-models-main technical parameters:

 

         Model      ME-D16      ME-D36        ME-D50
 Capacity(Kg/h)         0.5-5       5-20         15-50
Total power(KW)          10         30            50
Extrusion speed(rpm)       20-600    10-500        10-300
       External       dimension(mm) 2050*700*1560  3250*800*25003500*2250*2000
Total weight(Kg)         700        1200           2500
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